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K-Ras Mutations in Non-Small-Cell Lung Cancer : Prognostic and Predictive Value
Joint Authors
Cappuzzo, Federico
D’Arcangelo, Manolo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Non-small-cell lung cancer (NSCLC) is a heterogeneous disease due to the presence of different clinically relevant molecular subtypes.
Until today, several biological events have been identified in lung adenocarcinoma, including epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) translocations, offering new hopes to patients with metastatic disease.
Unfortunately, in approximately 50% of adenocarcinoma and for those harbouring K-RAS mutations, the most frequent mutation in Caucasian lung adenocarcinoma, so far no specific drug demonstrated efficacy.
The rat sarcoma (RAS) genes, including H-RAS, K-RAS, and N-RAS, encode a family of proteins regulating cell growth, differentiation, and apoptosis.
K-RAS mutations are present in 20–30% of NSCLC and occur most commonly, but not exclusively, in adenocarcinoma histology and life-long smokers.
Although in colorectal cancer patients K-RAS mutations represent a validated negative predictive biomarker for treatment with anti-EGFR monoclonal antibodies, their role in selecting specific treatment for NSCLC patients remains undefined.
Aim of the present paper is to critically analyze the prognostic and predictive value of K-RAS mutations in NSCLC.
American Psychological Association (APA)
D’Arcangelo, Manolo& Cappuzzo, Federico. 2012. K-Ras Mutations in Non-Small-Cell Lung Cancer : Prognostic and Predictive Value. ISRN Molecular Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502097
Modern Language Association (MLA)
D’Arcangelo, Manolo& Cappuzzo, Federico. K-Ras Mutations in Non-Small-Cell Lung Cancer : Prognostic and Predictive Value. ISRN Molecular Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-502097
American Medical Association (AMA)
D’Arcangelo, Manolo& Cappuzzo, Federico. K-Ras Mutations in Non-Small-Cell Lung Cancer : Prognostic and Predictive Value. ISRN Molecular Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502097
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502097