Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells
Joint Authors
Lee, Won-Sup
Moon, Dong-Oh
Kim, Mun-Ock
Kim, Gi-Young
Jung, Jin Myung
Choi, Yung Hyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Agaricus blazei is widely accepted as a traditional medicinal mushroom, and it has been known to exhibit immunostimulatory and anti-cancer activity.
However, the apoptotic mechanism in cancer cells is poorly understood.
In this study, we have investigated whether A.
blazei extract (ABE) exerts antiproliferative and apoptotic effects in human leukemic THP-1 cells.
We observed that ABE-induced apoptosis is associated with the mitochondrial pathway, which is mediated by reactive oxygen species (ROS) generation and prolonged c-Jun N-terminal kinase (JNK) activation.
In addition, the ABE treatment resulted in the accumulation of cytochrome c in the cytoplasm, an increase in caspase activity, and an upregulation of Bax and Bad.
With those results in mind, we found that ABE decreases constitutive NF-κB activation and NF-κB-regulated gene products such as IAP-1 and -2.
We concluded that ABE induces apoptosis with ROS-dependent JNK activation and constitutive activated NF-κB inhibition in THP-1 cells.
American Psychological Association (APA)
Kim, Mun-Ock& Moon, Dong-Oh& Jung, Jin Myung& Lee, Won-Sup& Choi, Yung Hyun& Kim, Gi-Young. 2011. Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-502184
Modern Language Association (MLA)
Kim, Mun-Ock…[et al.]. Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-502184
American Medical Association (AMA)
Kim, Mun-Ock& Moon, Dong-Oh& Jung, Jin Myung& Lee, Won-Sup& Choi, Yung Hyun& Kim, Gi-Young. Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-502184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502184