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Norcantharidin, Derivative of Cantharidin, for Cancer Stem Cells
Joint Authors
Liao, Hui-Fen
Hsieh, Chen-Hsi
Chao, K. S. Clifford
Chen, Yu-Jen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cancer stem cells (CSCs) existing in human cancers have been demonstrated to be a major cause of cancer treatment resistance, invasion, metastasis, and relapse.
Self-renewal pathways, Wnt/β-catenin, Sonic hedgehog (Shh), and the Notch signaling pathway play critical roles in developing CSCs and lead to angiogenesis, migration, invasion, and metastasis.
Multidrug resistance (MDR) is an unfavorable factor causing the failure of treatments against cancer cells.
The most important and thoroughly studied mechanism involved in MDR is the active efflux of chemotherapeutic agents through membrane drug transporters.
There is growing evidence that Norcantharidin (NCTD), a water-soluble synthetic small molecule derivative of naturally occurring cantharidin from the medicinal insect blister beetle (Mylabris phalerata Pallas), is capable of chemoprevention and tumor inhibition.
We summarize investigations into the modulation of self-renewal pathways and MDR in CSCs by NCTD.
This review may aid in further investigation of using NCTD to develop more effective strategies for cancer treatment to reduce resistance and recurrence.
American Psychological Association (APA)
Hsieh, Chen-Hsi& Chao, K. S. Clifford& Liao, Hui-Fen& Chen, Yu-Jen. 2013. Norcantharidin, Derivative of Cantharidin, for Cancer Stem Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-502226
Modern Language Association (MLA)
Hsieh, Chen-Hsi…[et al.]. Norcantharidin, Derivative of Cantharidin, for Cancer Stem Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-502226
American Medical Association (AMA)
Hsieh, Chen-Hsi& Chao, K. S. Clifford& Liao, Hui-Fen& Chen, Yu-Jen. Norcantharidin, Derivative of Cantharidin, for Cancer Stem Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-502226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502226