ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats
Joint Authors
Haddad, Georges E.
Alvin, Zikiar V.
Hajj-Mousssa, Wissam
Millis, Richard M.
Source
International Journal of Cell Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
ATP-sensitive potassium channels (KATP) protect the myocardium from hypertrophy induced by pressure-overloading.
In this study, we determined the effects of these channels in volume-overloading.
We compared the effects of a KATP agonist and a KATP antagonist on sarcolemmal transmembrane current density (pA/pF) clamped at 20 mV increments of membrane potential from −80 to +40 mV in ventricular cardiac myocytes.
The basal outward potassium pA/pF in myocytes of volume-overloaded animals was significantly smaller than that in the myocytes of sham-operated controls.
Treatment of the control myocytes with the KATP agonist cromakalim increased pA/pF significantly.
This increase was blocked by the KATP antagonist glibenclamide.
Treatment of the hypertrophied myocytes from volume-overloaded animals with cromakalim and in the presence and absence of glibenclamide did not change pA/pF significantly.
These findings suggest that eccentrically hypertrophied cardiac myocytes from volume-overloading may be unresponsive to specific activation/inactivation of KATP and that dysfunctional KATP may fail to protect the myocardium from left ventricular hypertrophy associated with volume-overloading.
American Psychological Association (APA)
Alvin, Zikiar V.& Millis, Richard M.& Hajj-Mousssa, Wissam& Haddad, Georges E.. 2011. ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-502249
Modern Language Association (MLA)
Alvin, Zikiar V.…[et al.]. ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats. International Journal of Cell Biology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-502249
American Medical Association (AMA)
Alvin, Zikiar V.& Millis, Richard M.& Hajj-Mousssa, Wissam& Haddad, Georges E.. ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-502249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502249