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Dietary Phenolic Acids Act as Effective Antioxidants in Membrane Models and in Cultured Cells, Exhibiting Proapoptotic Effects in Leukaemia Cells
Joint Authors
Fiorentini, Diana
Prata, Cecilia
Caliceti, Cristiana
Vieceli Dalla Sega, Francesco
Landi, Laura
Hrelia, Silvana
Zambonin, Laura
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Caffeic, syringic, and protocatechuic acids are phenolic acids derived directly from food intake or come from the gut metabolism of polyphenols.
In this study, the antioxidant activity of these compounds was at first evaluated in membrane models, where caffeic acid behaved as a very effective chain-breaking antioxidant, whereas syringic and protocatechuic acids were only retardants of lipid peroxidation.
However, all three compounds acted as good scavengers of reactive species in cultured cells subjected to exogenous oxidative stress produced by low level of H2O2.
Many tumour cells are characterised by increased ROS levels compared with their noncancerous counterparts.
Therefore, we investigated whether phenolic acids, at low concentrations, comparable to those present in human plasma, were able to decrease basal reactive species.
Results show that phenolic acids reduced ROS in a leukaemia cell line (HEL), whereas no effect was observed in normal cells, such as HUVEC.
The compounds exhibited no toxicity to normal cells while they decreased proliferation in leukaemia cells, inducing apoptosis.
In the debate on optimal ROS-manipulating strategies in cancer therapy, our work in leukaemia cells supports the antioxidant ROS-depleting approach.
American Psychological Association (APA)
Zambonin, Laura& Caliceti, Cristiana& Vieceli Dalla Sega, Francesco& Fiorentini, Diana& Hrelia, Silvana& Landi, Laura…[et al.]. 2012. Dietary Phenolic Acids Act as Effective Antioxidants in Membrane Models and in Cultured Cells, Exhibiting Proapoptotic Effects in Leukaemia Cells. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-502277
Modern Language Association (MLA)
Zambonin, Laura…[et al.]. Dietary Phenolic Acids Act as Effective Antioxidants in Membrane Models and in Cultured Cells, Exhibiting Proapoptotic Effects in Leukaemia Cells. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-502277
American Medical Association (AMA)
Zambonin, Laura& Caliceti, Cristiana& Vieceli Dalla Sega, Francesco& Fiorentini, Diana& Hrelia, Silvana& Landi, Laura…[et al.]. Dietary Phenolic Acids Act as Effective Antioxidants in Membrane Models and in Cultured Cells, Exhibiting Proapoptotic Effects in Leukaemia Cells. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-502277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502277