Patients with Obstructive Sleep Apnea Display Increased Carotid Intima Media : A Meta-Analysis
Joint Authors
Nadeem, Rashid
Baessler, Aaron
Singh, Mukesh
Khan, Mahnoor
Harvey, Michael
Sajid, Hassan
Navid, Nayab
Madbouly, Essam M.
Albustani, Mustafa
Khan, Ahmed Abdullah
Source
International Journal of Vascular Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Obstructive sleep apnea (OSA) is associated with coronary artery disease.
Intermittent hypoxia associated with OSA increases sympathetic activity and may cause systemic inflammation, which may contribute to atherosclerosis leading to an increase in the size of carotid intima media thickness (CIMT).
Methods.
PubMed and Cochrane library were reviewed by utilizing different combinations of key words: sleep apnea, carotid disease, intima media thickness, and carotid atherosclerosis.
Inclusion criteria were English articles; studies with adult population with OSA and without OSA; CIMT recorded by ultrasound in mean and standard deviation or median with 95% confidence interval; and OSA defined as apnea hypopnea index of ≥5/h.
A total of 95 studies were reviewed for inclusion, with 16 studies being pooled for analysis.
Results.
Ninety-five studies were reviewed, while 16 studies were pooled for analysis; since some studies have more than one data set, there were 25 data sets with 1415 patients being pooled for meta-analysis.
All studies used ultrasound to measure CIMT.
CIMT standardized difference in means ranged from −0.883 to 8.01.
The pooled standardized difference in means was 1.40 (lower limit 0.996 to upper limit 1.803, (P<0.0001).
Conclusion.
Patients with OSA appear to have increased CIMT suggestive of an atherosclerotic process.
American Psychological Association (APA)
Nadeem, Rashid& Harvey, Michael& Singh, Mukesh& Khan, Ahmed Abdullah& Albustani, Mustafa& Baessler, Aaron…[et al.]. 2013. Patients with Obstructive Sleep Apnea Display Increased Carotid Intima Media : A Meta-Analysis. International Journal of Vascular Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502313
Modern Language Association (MLA)
Nadeem, Rashid…[et al.]. Patients with Obstructive Sleep Apnea Display Increased Carotid Intima Media : A Meta-Analysis. International Journal of Vascular Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-502313
American Medical Association (AMA)
Nadeem, Rashid& Harvey, Michael& Singh, Mukesh& Khan, Ahmed Abdullah& Albustani, Mustafa& Baessler, Aaron…[et al.]. Patients with Obstructive Sleep Apnea Display Increased Carotid Intima Media : A Meta-Analysis. International Journal of Vascular Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502313