New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy
Joint Authors
Bellizzi, Anna
Pietropaolo, Valeria
Palamara, Anna Teresa
Rodio, Donatella Maria
Nencioni, Lucia
Anzivino, Elena
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
John Cunningham virus (JCV) is a member of the Polyomaviridae family.
It was first isolated from the brain of a patient with Hodgkin disease in 1971, and since then the etiological agent of the progressive multifocal leukoencephalopathy (PML) was considered.
Until the human immunodeficiency virus (HIV) pandemic, PML was rare: in fact HIV-induced immunodeficiency is the most common predisposing factor accounting for 85% of all instances of PML.
This data led to intense research on JCV infection and resulted in better understanding of epidemiology and clinic-pathologic spectrum.
Recently, cases of PML have been observed after the introduction of monoclonal antibodies, such as natalizumab, rituximab, efalizumab, and infliximab, in the treatment of autoimmune disease, underlining the important role of host immunity in PML pathogenesis.
In this review current understanding of the JCV infection and the new findings relating to the pathogenesis of PML has been comprehensively revised, focusing our attention on the interaction between the cellular and viral molecular pathways implicated in the JCV infection and the modulating role of host immune surveillance in the viral reactivation from a latent state.
American Psychological Association (APA)
Bellizzi, Anna& Anzivino, Elena& Rodio, Donatella Maria& Palamara, Anna Teresa& Nencioni, Lucia& Pietropaolo, Valeria. 2013. New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-502328
Modern Language Association (MLA)
Bellizzi, Anna…[et al.]. New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy. Clinical and Developmental Immunology No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-502328
American Medical Association (AMA)
Bellizzi, Anna& Anzivino, Elena& Rodio, Donatella Maria& Palamara, Anna Teresa& Nencioni, Lucia& Pietropaolo, Valeria. New Insights on Human Polyomavirus JC and Pathogenesis of Progressive Multifocal Leukoencephalopathy. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-502328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502328