![](/images/graphics-bg.png)
Cognitive-Enhancing Effects of Polygalasaponin Hydrolysate in Aβ25–35-Induced Amnesic Mice
Joint Authors
Xu, Shu ping
Li, PengTao
Yang, Yan yan
Liu, Xin min
Xue, Dan
Pan, Rui le
Fan, Tai-Ping
Liu, Jin xiu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Polygalasaponins are the major active constituents of Polygala tenuifolia exhibiting antiamnesic activity, but their applications are limited due to their toxicities.
Evidence showed that the toxicities can be attenuated by hydrolysis.
Herein, effects of a hydrolysate of polygalasaponins (HPS) on cognitive impairment induced by Aβ25−35 were assessed by Morris water maze and step-through passive avoidance tests.
The impaired spatial reference memory was improved by HPS (50 and 100 mg/kg).
In the acquisition trial of step-through test, HPS (50 and 100 mg/kg) increased the latency into the dark chamber and decreased the error frequency significantly (P<.05).
However, no significant change was observed during the retention trial.
Additionally, HPS increased the corresponding SOD activities (62.34%, 22.09%) and decreased MDA levels (28.21%, 32.35%) in both cortex and hippocampus as compared to model animals.
These results show that HPS may be a useful treatment against amnesia probably via its antioxidant properties.
American Psychological Association (APA)
Xu, Shu ping& Yang, Yan yan& Xue, Dan& Liu, Jin xiu& Liu, Xin min& Fan, Tai-Ping…[et al.]. 2011. Cognitive-Enhancing Effects of Polygalasaponin Hydrolysate in Aβ25–35-Induced Amnesic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-502329
Modern Language Association (MLA)
Xu, Shu ping…[et al.]. Cognitive-Enhancing Effects of Polygalasaponin Hydrolysate in Aβ25–35-Induced Amnesic Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-502329
American Medical Association (AMA)
Xu, Shu ping& Yang, Yan yan& Xue, Dan& Liu, Jin xiu& Liu, Xin min& Fan, Tai-Ping…[et al.]. Cognitive-Enhancing Effects of Polygalasaponin Hydrolysate in Aβ25–35-Induced Amnesic Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-502329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502329