metaP-Server : A Web-Based Metabolomics Data Analysis Tool
Joint Authors
Kastenmüller, Gabi
Altmaier, Elisabeth
Wägele, Brigitte
Römisch-Margl, Werner
Suhre, Karsten
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Metabolomics is an emerging field that is based on the quantitative measurement of as many small organic molecules occurring in a biological sample as possible.
Due to recent technical advances, metabolomics can now be used widely as an analytical high-throughput technology in drug testing and epidemiological metabolome and genome wide association studies.
Analogous to chip-based gene expression analyses, the enormous amount of data produced by modern kit-based metabolomics experiments poses new challenges regarding their biological interpretation in the context of various sample phenotypes.
We developed metaP-server to facilitate data interpretation.
metaP-server provides automated and standardized data analysis for quantitative metabolomics data, covering the following steps from data acquisition to biological interpretation: (i) data quality checks, (ii) estimation of reproducibility and batch effects, (iii) hypothesis tests for multiple categorical phenotypes, (iv) correlation tests for metric phenotypes, (v) optionally including all possible pairs of metabolite concentration ratios, (vi) principal component analysis (PCA), and (vii) mapping of metabolites onto colored KEGG pathway maps.
Graphical output is clickable and cross-linked to sample and metabolite identifiers.
Interactive coloring of PCA and bar plots by phenotype facilitates on-line data exploration.
For users of commercial metabolomics kits, cross-references to the HMDB, LipidMaps, KEGG, PubChem, and CAS databases are provided.
metaP-server is freely accessible at http://metabolomics.helmholtz-muenchen.de/metap2/.
American Psychological Association (APA)
Kastenmüller, Gabi& Römisch-Margl, Werner& Wägele, Brigitte& Altmaier, Elisabeth& Suhre, Karsten. 2010. metaP-Server : A Web-Based Metabolomics Data Analysis Tool. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-502349
Modern Language Association (MLA)
Kastenmüller, Gabi…[et al.]. metaP-Server : A Web-Based Metabolomics Data Analysis Tool. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-502349
American Medical Association (AMA)
Kastenmüller, Gabi& Römisch-Margl, Werner& Wägele, Brigitte& Altmaier, Elisabeth& Suhre, Karsten. metaP-Server : A Web-Based Metabolomics Data Analysis Tool. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-502349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502349