Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo
Joint Authors
Miyachi, Hiroyuki
Sugimoto, Yukio
Yamamoto, Atsuki
Kakuta, Hiroki
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs).
It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice.
Therefore, it is suggested that the endogenous RXR ligand is involved in the PPARγ agonist-induced anti-inflammatory effect.
However, the participation of the RXR ligand in the PPARγ-induced anti-inflammatory effect is unknown.
Here, we investigated the influence of RXR antagonist on the anti-inflammatory effect of PPARγ agonist pioglitazone in carrageenan test.
In addition, we also examined the influence of PPAR antagonist on the anti-inflammatory effect induced by RXR agonist NEt-3IP.
The RXR antagonist suppressed the antiedema effect of PPARγ agonist.
In addition, the anti-inflammatory effect of RXR agonist was suppressed by PPARγ antagonist.
PPARγ agonist-induced anti-inflammatory effects were reversed by the RXR antagonist.
Thus, we showed that the endogenous RXR ligand might contribute to the PPARγ agonist-induced anti-inflammatory effect.
American Psychological Association (APA)
Yamamoto, Atsuki& Kakuta, Hiroki& Miyachi, Hiroyuki& Sugimoto, Yukio. 2011. Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo. PPAR Research،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-502360
Modern Language Association (MLA)
Yamamoto, Atsuki…[et al.]. Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo. PPAR Research No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-502360
American Medical Association (AMA)
Yamamoto, Atsuki& Kakuta, Hiroki& Miyachi, Hiroyuki& Sugimoto, Yukio. Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo. PPAR Research. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-502360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502360