Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor γ Agonist In Vivo

Abstract EN

Peroxisome proliferator-activated receptor γ (PPARγ) forms a heterodimeric DNA-binding complex with retinoid X receptors (RXRs).

It has been reported that the effect of the PPAR agonist is reduced in hepatocyte RXR-deficient mice.

Therefore, it is suggested that the endogenous RXR ligand is involved in the PPARγ agonist-induced anti-inflammatory effect.

However, the participation of the RXR ligand in the PPARγ-induced anti-inflammatory effect is unknown.

Here, we investigated the influence of RXR antagonist on the anti-inflammatory effect of PPARγ agonist pioglitazone in carrageenan test.

In addition, we also examined the influence of PPAR antagonist on the anti-inflammatory effect induced by RXR agonist NEt-3IP.

The RXR antagonist suppressed the antiedema effect of PPARγ agonist.

In addition, the anti-inflammatory effect of RXR agonist was suppressed by PPARγ antagonist.

PPARγ agonist-induced anti-inflammatory effects were reversed by the RXR antagonist.

Thus, we showed that the endogenous RXR ligand might contribute to the PPARγ agonist-induced anti-inflammatory effect.