Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats
Joint Authors
Saba El-Rigal, Nagy
Ali, Sanaa A.
Hamed, Manal A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The objective of this study was to evaluate the potential of successive ginger extracts (petroleum ether, chloroform, and ethanol) against nephrotoxicity induced by CCl4 in rats.
The evaluation was done through measuring kidney antioxidant parameters: glutathione (GSH), lipid peroxides (LPO), and superoxide dismutase (SOD).
Renal function test: urea, creatinine and serum protein values, were also evaluated.
The work was extended to examine tissue inflammatory mediators, prostaglandin-E2 (PGE2), collagen content and the kidney histopathology.
Severe alterations in all biomarkers were observed after injury with CCl4.
Treatment with ginger extracts resulted in markedly decreased levels of LPO, PGE2, collagen and kidney function tests, while increased levels of GSH, SOD and serum protein were observed.
In conclusion, extracts of ginger, particularly the ethanol, resulted in an attractive candidate for the treatment of nephropathy induced by CCl4 through scavenging free radicals, improved kidney functions, inhibition of inflammatory mediators, and normalizing the kidney histopathological architecture.
Further studies are required in order to identify the molecules responsible of the pharmacological activity.
American Psychological Association (APA)
Hamed, Manal A.& Ali, Sanaa A.& Saba El-Rigal, Nagy. 2012. Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-502389
Modern Language Association (MLA)
Hamed, Manal A.…[et al.]. Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats. The Scientific World Journal No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-502389
American Medical Association (AMA)
Hamed, Manal A.& Ali, Sanaa A.& Saba El-Rigal, Nagy. Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-502389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502389