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Combination Drug Therapy for Pain following Chronic Spinal Cord Injury
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
A number of mechanisms have been elucidated that maintain neuropathic pain due to spinal cord injury (SCI).
While target-based therapeutics are being developed based on elucidation of these mechanisms, treatment for neuropathic SCI pain has not been entirely satisfactory due in part to the significant convergence of neurological and inflammatory processes that maintain the neuropathic pain state.
Thus, a combination drug treatment strategy, wherein several pain-related mechanism are simultaneously engaged, could be more efficacious than treatment against individual mechanisms alone.
Also, by engaging several targets at once, it may be possible to reduce the doses of the individual drugs, thereby minimizing the potential for adverse side effects.
Positive preclinical and clinical studies have demonstrated improved efficacy of combination drug treatment over single drug treatment in neuropathic pain of peripheral origin, and perhaps such combinations could be utilized for neuropathic SCI pain.
At the same time, there are mechanisms that distinguish SCI from peripheral neuropathic pain, so novel combination therapies will be needed.
American Psychological Association (APA)
Hama, Aldric& Sagen, Jacqueline. 2012. Combination Drug Therapy for Pain following Chronic Spinal Cord Injury. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502399
Modern Language Association (MLA)
Hama, Aldric& Sagen, Jacqueline. Combination Drug Therapy for Pain following Chronic Spinal Cord Injury. Pain Research and Treatment No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-502399
American Medical Association (AMA)
Hama, Aldric& Sagen, Jacqueline. Combination Drug Therapy for Pain following Chronic Spinal Cord Injury. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502399