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Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I : C in Mice
Joint Authors
Wang, Chong
Xu, Xianxiang
Bian, Difei
He, Xin
Sheng, Rong
Pan, Rong
Dai, Yue
Qian, Cheng
Tang, Qin
Luo, Yubin
Gao, Xinghua
Li, Ying
Xia, Yufeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Radix Pseudostellariae is used as a tonic drug in traditional Chinese medicine with immunomodulating and anti-fatigue activities, and the polysaccharide is considered as the main active component.
The purpose of this study is to examine the effect of the polysaccharide isolated from Radix Pseudostellariae (PRP) on mouse chronic fatigue syndrome (CFS) induced by intraperitoneal injection of polyriboinosinic:polyribocytidylic acid (poly I:C), a double-stranded synthetic RNA.
It has shown that the fatigue symptom of mice lasted at least 1 week as evaluated by forced swimming time.
PRP (100, 200, 400 mg kg−1), orally administered 3 days before poly I:C injection, showed dose-dependent anti-fatigue effects.
In addition, poly I:C led to evident alternations in neuroendocrine and immune systems of mice, such as reduced spontaneous activity and learning ability, declined serum level of corticosterone, increased weight indexes and T lymphocyte numbers in thymuses and spleens, and increased CD4+/CD8+ ratio but decreased proliferation ability of T lymphocytes in spleens.
PRP alleviated the abnormalities caused by poly I:C, and restored the function of hosts to normal conditions.
The findings suggest that PRP is beneficial to CFS, and the underlying mechanisms of action involve neuroendocrine and immune systems.
American Psychological Association (APA)
Sheng, Rong& Xu, Xianxiang& Tang, Qin& Bian, Difei& Li, Ying& Qian, Cheng…[et al.]. 2011. Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I : C in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-502406
Modern Language Association (MLA)
Sheng, Rong…[et al.]. Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I : C in Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-502406
American Medical Association (AMA)
Sheng, Rong& Xu, Xianxiang& Tang, Qin& Bian, Difei& Li, Ying& Qian, Cheng…[et al.]. Polysaccharide of Radix Pseudostellariae Improves Chronic Fatigue Syndrome Induced by Poly I : C in Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-502406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502406