Structure-Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl Pyrophosphate Synthases
Joint Authors
Kuo, Chih-Jung
Liu, Hun-Ge
Liang, Po-Huang
Wang, Andrew H.-J.
Wu, Su-Ying
Lu, I-Lin
Ko, Tzu-Ping
Guo, Rey-Ting
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Helicobacter pylori colonizes the human gastric epithelium and causes diseases such as gastritis, peptic ulcers, and stomach cancer.
Undecaprenyl pyrophosphate synthase (UPPS), which catalyzes consecutive condensation reactions of farnesyl pyrophosphate with eight isopentenyl pyrophosphate to form lipid carrier for bacterial peptidoglycan biosynthesis, represents a potential target for developing new antibiotics.
In this study, we solved the crystal structure of H.
pylori UPPS and performed virtual screening of inhibitors from a library of 58,635 compounds.
Two hits were found to exhibit differential activities against Helicobacter pylori and Escherichia coli UPPS, giving the possibility of developing antibiotics specially targeting pathogenic H.
pylori without killing the intestinal E.
coli.
American Psychological Association (APA)
Kuo, Chih-Jung& Guo, Rey-Ting& Lu, I-Lin& Liu, Hun-Ge& Wu, Su-Ying& Ko, Tzu-Ping…[et al.]. 2008. Structure-Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl Pyrophosphate Synthases. Journal of Biomedicine and Biotechnology،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-502476
Modern Language Association (MLA)
Kuo, Chih-Jung…[et al.]. Structure-Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl Pyrophosphate Synthases. Journal of Biomedicine and Biotechnology No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-502476
American Medical Association (AMA)
Kuo, Chih-Jung& Guo, Rey-Ting& Lu, I-Lin& Liu, Hun-Ge& Wu, Su-Ying& Ko, Tzu-Ping…[et al.]. Structure-Based Inhibitors Exhibit Differential Activities against Helicobacter pylori and Escherichia coli Undecaprenyl Pyrophosphate Synthases. Journal of Biomedicine and Biotechnology. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-502476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502476