The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat
Joint Authors
Rash, Arjun
Ecelbarger, Carolyn M.
Sinha, Rajesh K.
Tiwari, Swasti
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The effect of candesartan, an angiotensin-II type-1 receptor antagonist, on the metabolic profile and renal inflammation is unclear.
We evaluated this relationship by feeding male lean (LZ) and obese (OZ) Zucker rats chow or chow with candesartan (23.5 mg/kg⋅diet) for 14 weeks (n=6–8/treatment/body type).
Candesartan reduced serum triglycerides, plasma creatinine, urine albumin, and renal cortical collagen and glycogen deposition in the OZ.
An ELISA-based cytokine array revealed that candesartan normalized elevated renal interleukin (IL) 1-β and monocyte chemoattractant protein-1 (MCP-1) levels in OZ.
Nonetheless, candesartan impaired glucose tolerance, and did not lower blood insulin or glucose levels.
Moreover, renal IL-1α, -2, -4, -6 and -10 tumor necrosis factor-α, interferon-γ, were significantly reduced in OZ relative to LZ, and increased by candesartan.
Furthermore, candesartan increased growth-regulated oncogene, transforming growth factor-β1 and IL-18 in OZ kidneys to a level higher than LZ or untreated OZ.
Candesartan did not affect renal cytokine levels in LZ.
Overall, candesartan attenuated renal disease and improved renal function in OZ, despite mixed effects on metabolic factors and cytokines.
Reduced plasma triglycerides and/or renal MCP-1 and IL-1β may have had a role in this protection.
However, these effects were clearly independent of any improvement in glucose tolerance.
American Psychological Association (APA)
Ecelbarger, Carolyn M.& Rash, Arjun& Sinha, Rajesh K.& Tiwari, Swasti. 2010. The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-502479
Modern Language Association (MLA)
Ecelbarger, Carolyn M.…[et al.]. The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat. Mediators of Inflammation No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-502479
American Medical Association (AMA)
Ecelbarger, Carolyn M.& Rash, Arjun& Sinha, Rajesh K.& Tiwari, Swasti. The Effect of Chronic Candesartan Therapy on the Metabolic Profile and Renal Tissue Cytokine Levels in the Obese Zucker Rat. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-502479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502479