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Endoplasmic Reticulum Stress and Lipid Metabolism : Mechanisms and Therapeutic Potential
Joint Authors
Basseri, Sana
Austin, Richard C.
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The endoplasmic reticulum (ER) plays a crucial role in protein folding, assembly, and secretion.
Disruption of ER homeostasis may lead to accumulation of misfolded or unfolded proteins in the ER lumen, a condition referred to as ER stress.
In response to ER stress, a signal transduction pathway known as the unfolded protein response (UPR) is activated.
UPR activation allows the cell to cope with an increased protein-folding demand on the ER.
Recent studies have shown that ER stress/UPR activation plays a critical role in lipid metabolism and homeostasis.
ER-stress-dependent dysregulation of lipid metabolism may lead to dyslipidemia, insulin resistance, cardiovascular disease, type 2 diabetes, and obesity.
In this paper, we examine recent findings illustrating the important role ER stress/UPR signalling pathways play in regulation of lipid metabolism, and how they may lead to dysregulation of lipid homeostasis.
American Psychological Association (APA)
Basseri, Sana& Austin, Richard C.. 2011. Endoplasmic Reticulum Stress and Lipid Metabolism : Mechanisms and Therapeutic Potential. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502483
Modern Language Association (MLA)
Basseri, Sana& Austin, Richard C.. Endoplasmic Reticulum Stress and Lipid Metabolism : Mechanisms and Therapeutic Potential. Biochemistry Research International No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-502483
American Medical Association (AMA)
Basseri, Sana& Austin, Richard C.. Endoplasmic Reticulum Stress and Lipid Metabolism : Mechanisms and Therapeutic Potential. Biochemistry Research International. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502483