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Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation
Joint Authors
Weimar, Willem
Betjes, Michiel G. H.
Litjens, Nicolle H. R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Proinflammatory CD4+ T cells without the costimulatory molecule CD28 (CD4+CD28null T cells) are expanded in patients with end-stage renal disease (ESRD) and associated with atherosclerotic vascular events (AVE).
In a prospective study, the number of circulating CD4+CD28null T cells was established in 295 ESRD patients prior to receiving a kidney allograft.
Within the first year after transplantation, an AVE occurred in 20 patients.
Univariate analysis showed that besides a history of cardiovascular disease (CVDpos, HR 8.1, P<0.001), age (HR 1.04, P=0.02), dyslipidaemia (HR 8.8, P=0.004), and the % of CD4+CD28null T cells (HR 1.04 per % increase, 95% CI 1.00–1.09, P=0.01) were significantly associated with the occurrence of a posttransplantation AVE.
In a multivariate analysis, only CVDpos remained a significant risk factor with a significant and positive interaction between the terms CVDpos and the % of CD4+CD28null T cells (HR 1.05, 95% CI 1.03–1.11, P<0.001).
Within the CVDpos group, the incidence of an AVE was 13% in the lowest tertile compared to 25% in the highest tertile of % of CD4+CD28null T cells.
In conclusion, the presence of circulating CD4+CD28null T cells is associated with an increased risk for a cardiovascular event shortly after kidney transplantation.
American Psychological Association (APA)
Betjes, Michiel G. H.& Weimar, Willem& Litjens, Nicolle H. R.. 2013. Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation. Journal of Transplantation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502490
Modern Language Association (MLA)
Betjes, Michiel G. H.…[et al.]. Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation. Journal of Transplantation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-502490
American Medical Association (AMA)
Betjes, Michiel G. H.& Weimar, Willem& Litjens, Nicolle H. R.. Circulating CD4+CD28null T Cells May Increase the Risk of an Atherosclerotic Vascular Event Shortly after Kidney Transplantation. Journal of Transplantation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502490