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Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents
Joint Authors
Ueda-Nakamura, Tânia
Costa, Marco Antonio
Palazzo de Mello, João Carlos
Dias Filho, Benedito Prado
Nakamura, Celso Vataru
Kaneshima, Edílson Nobuyoshi
Audi, Elisabeth Aparecida
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis.
The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S.
adstringens in rodents.
In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD50 of 3.015 mg·kg−1.
In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200 mg·kg−1).
In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls.
The present results indicate that F2 from the stem bark of S.
adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.
American Psychological Association (APA)
Costa, Marco Antonio& Palazzo de Mello, João Carlos& Kaneshima, Edílson Nobuyoshi& Ueda-Nakamura, Tânia& Dias Filho, Benedito Prado& Audi, Elisabeth Aparecida…[et al.]. 2013. Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-502507
Modern Language Association (MLA)
Costa, Marco Antonio…[et al.]. Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-502507
American Medical Association (AMA)
Costa, Marco Antonio& Palazzo de Mello, João Carlos& Kaneshima, Edílson Nobuyoshi& Ueda-Nakamura, Tânia& Dias Filho, Benedito Prado& Audi, Elisabeth Aparecida…[et al.]. Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-502507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502507