Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure
Joint Authors
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Brain edema in acute liver failure (ALF) remains lethal.
Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored.
Intact tight junctions (TJs) between brain capillary endothelial cells are critical for normal BBB function.
Recent reports found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity.
However, the role of TJ in ALF has not been completely understood.
This paper reviews the role of the paracellular tight junction in the increased selective BBB permeability that leads to brain edema in ALF and furthermore explores the effect of systemic inflammatory cytokines on the tight junction dysfunction.
American Psychological Association (APA)
Cui, Wei& Sun, Cui-Ming& Liu, Pei. 2013. Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-502525
Modern Language Association (MLA)
Cui, Wei…[et al.]. Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure. Gastroenterology Research and Practice No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-502525
American Medical Association (AMA)
Cui, Wei& Sun, Cui-Ming& Liu, Pei. Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-502525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502525