A Systematic Review of the Epidemiology, Immunopathogenesis, Diagnosis, and Treatment of Pleural TB in HIV- Infected Patients
Joint Authors
Aljohaney, A.
Alvarez, G. G.
Amjadi, K.
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
High HIV burden countries have experienced a high burden of pleural TB in HIV-infected patients.
Objective.
To review the epidemiology, immunopathogenesis, diagnosis, and treatment of pleural TB in HIV-infected patients.
Methods.
A literature search from 1950 to June 2011 in MEDLINE was conducted.
Results.
Two-hundred and ninety-nine studies were identified, of which 30 met the inclusion criteria.
The immunopathogenesis as denoted by cells and cytokine profiles is distinctly different between HIV and HIV-uninfected pleural TB disease.
Adenosine deaminase and interferon gamma are good markers of pleural TB disease even in HIV-infected patients.
HIV-uninfected TB suspects with pleural effusions commonly have a low yield of TB organisms however the evidence suggests that in dually infected patients smear and cultures have a higher yield.
The Gene Xpert MTB/RIF assay has significant potential to improve the diagnosis of pleural TB in HIV-positive patients.
Conclusions.
Pleural TB in HIV-infected patients has a different immunopathogenesis than HIV-uninfected pleural TB and these findings in part support the differences noted in this systematic review.
Research should focus on developing an interferon gamma-based point of care diagnostic test and expansion of the role of Gene Xpert in the diagnosis of pleural TB.
American Psychological Association (APA)
Aljohaney, A.& Amjadi, K.& Alvarez, G. G.. 2012. A Systematic Review of the Epidemiology, Immunopathogenesis, Diagnosis, and Treatment of Pleural TB in HIV- Infected Patients. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-502562
Modern Language Association (MLA)
Aljohaney, A.…[et al.]. A Systematic Review of the Epidemiology, Immunopathogenesis, Diagnosis, and Treatment of Pleural TB in HIV- Infected Patients. Clinical and Developmental Immunology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-502562
American Medical Association (AMA)
Aljohaney, A.& Amjadi, K.& Alvarez, G. G.. A Systematic Review of the Epidemiology, Immunopathogenesis, Diagnosis, and Treatment of Pleural TB in HIV- Infected Patients. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-502562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502562