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Tyrosine Kinase Inhibitors in the Treatment of Systemic Sclerosis : The Difficulty in Interpreting Proof-of-Concept Studies
Joint Authors
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Tyrosine kinase inhibitors (TKIs) have emerged as a targeted therapy of interest for the treatment of systemic sclerosis (SSc).
Recently, several groups have performed pilot or “proof-of-concept” studies to determine the feasibility of this approach for the treatment of the cutaneous and pulmonary manifestations of this multisystem disease.
The conclusions drawn by these different studies have been conflicting, and some controversy has arisen as to whether tyrosine kinase inhibition is a treatment approach worthy of continued study.
This paper summarizes this research to date with emphasis on the challenges in interpreting proof-of-concept studies in this patient group.
American Psychological Association (APA)
Gordon, Jessica& Spiera, Robert. 2011. Tyrosine Kinase Inhibitors in the Treatment of Systemic Sclerosis : The Difficulty in Interpreting Proof-of-Concept Studies. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-502573
Modern Language Association (MLA)
Gordon, Jessica& Spiera, Robert. Tyrosine Kinase Inhibitors in the Treatment of Systemic Sclerosis : The Difficulty in Interpreting Proof-of-Concept Studies. International Journal of Rheumatology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-502573
American Medical Association (AMA)
Gordon, Jessica& Spiera, Robert. Tyrosine Kinase Inhibitors in the Treatment of Systemic Sclerosis : The Difficulty in Interpreting Proof-of-Concept Studies. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-502573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502573