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How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System
Joint Authors
Prisco, A.
De Berardinis, Piergiuseppe
Castiglione, Filippo
Mantile, F.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The immune system is able to respond more vigorously to the second contact with a given antigen than to the first contact.
Vaccination protocols generally include at least two doses, in order to obtain high antibody titers.
We want to analyze the relation between the time elapsed from the first dose (priming) and the second dose (boost) on the antibody titers.
In this paper, we couple in vivo experiments with computer simulations to assess the effect of delaying the second injection.
We observe that an interval of several weeks between the prime and the boost is necessary to obtain optimal antibody responses.
American Psychological Association (APA)
Castiglione, Filippo& Mantile, F.& De Berardinis, Piergiuseppe& Prisco, A.. 2012. How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-502578
Modern Language Association (MLA)
Castiglione, Filippo…[et al.]. How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-502578
American Medical Association (AMA)
Castiglione, Filippo& Mantile, F.& De Berardinis, Piergiuseppe& Prisco, A.. How the Interval between Prime and Boost Injection Affects the Immune Response in a Computational Model of the Immune System. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-502578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502578