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Polymorphisms in the RANKRANKL Genes and Their Effect on Bone Specific Prognosis in Breast Cancer Patients
Joint Authors
Schulz-Wendtland, Rüdiger
Strick, Reiner
Hartmann, Arndt
Ekici, Arif B.
Bayer, Christian M.
Heusinger, Katharina
Hein, Alexander
Renner, Stefan P.
Beckmann, Matthias W.
Fasching, Peter A.
Häberle, Lothar
Ruebner, Matthias
Lux, Michael P.
Schrauder, Michael G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The receptor activator of NF-κB (RANK) pathway is involved in bone health as well as breast cancer (BC) pathogenesis and progression.
Whereas the therapeutic implication of this pathway is established for the treatment of osteoporosis and bone metastases, the application in adjuvant BC is currently investigated.
As genetic variants in this pathway have been described to influence bone health, aim of this study was the prognostic relevance of genetic variants in RANK and RANKL.
Single nucleotide polymorphisms in RANK(L) (rs1054016/rs1805034/rs35211496) were genotyped and analyzed with regard to bone metastasis-free survival (BMFS), disease-free survival, and overall survival for a retrospective cohort of 1251 patients.
Cox proportional hazard models were built to examine the prognostic influence in addition to commonly established prognostic factors.
The SNP rs1054016 seems to influence BMFS.
Patients with two minor alleles had a more favorable prognosis than patients with at least one common allele (HR 0.37 (95% CI: 0.17, 0.84)), whereas other outcome parameters remained unaffected.
rs1805034 and rs35211496 had no prognostic relevance.
The effect of rs1054016(RANKL) adds to the evidence that the RANK pathway plays a role in BC pathogenesis and progression with respect to BMFS, emphasizing the connection between BC and bone health.
American Psychological Association (APA)
Hein, Alexander& Bayer, Christian M.& Schrauder, Michael G.& Häberle, Lothar& Heusinger, Katharina& Strick, Reiner…[et al.]. 2014. Polymorphisms in the RANKRANKL Genes and Their Effect on Bone Specific Prognosis in Breast Cancer Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-502591
Modern Language Association (MLA)
Hein, Alexander…[et al.]. Polymorphisms in the RANKRANKL Genes and Their Effect on Bone Specific Prognosis in Breast Cancer Patients. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-502591
American Medical Association (AMA)
Hein, Alexander& Bayer, Christian M.& Schrauder, Michael G.& Häberle, Lothar& Heusinger, Katharina& Strick, Reiner…[et al.]. Polymorphisms in the RANKRANKL Genes and Their Effect on Bone Specific Prognosis in Breast Cancer Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-502591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502591