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Bridging Molecular Genetics and Biomarkers in Lewy Body and Related Disorders
Joint Authors
Sekiyama, Kazunari
Liang, Willie
Hashimoto, Makoto
Waragai, Masaaki
Masliah, Eliezer
Ho, Gilbert J.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-03
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Recent advances have been made in defining the genetic and molecular basis of dementia with Lewy bodies (DLBs) and related neurodegenerative disorders such as Parkinson's disease (PD) and Parkinson's disease dementia (PDD) which comprise the spectrum of “Lewy body disorders” (LBDs).
The genetic alterations and underlying disease mechanisms in the LBD overlap substantially, suggesting common disease mechanisms.
As with the other neurodegenerative dementias, early diagnosis in LBD or even identification prior to symptom onset is key to developing effective therapeutic strategies, but this is dependent upon the development of robust, specific, and sensitive biomarkers as diagnostic tools and therapeutic endpoints.
Recently identified mutations in the synucleins and other relevant genes in PD and DLB as well as related biomolecular pathways suggest candidate markers from biological fluids and imaging modalities that reflect the underlying disease mechanisms.
In this context, several promising biomarkers for the LBD have already been identified and examined, while other intriguing possible candidates have recently emerged.
Challenges remain in defining their correlation with pathological processes and their ability to detect DLB and related disorders, and perhaps a combined array of biomarkers may be needed to distinguish various LBDs.
American Psychological Association (APA)
Ho, Gilbert J.& Liang, Willie& Waragai, Masaaki& Sekiyama, Kazunari& Masliah, Eliezer& Hashimoto, Makoto. 2011. Bridging Molecular Genetics and Biomarkers in Lewy Body and Related Disorders. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-502593
Modern Language Association (MLA)
Ho, Gilbert J.…[et al.]. Bridging Molecular Genetics and Biomarkers in Lewy Body and Related Disorders. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-18.
https://search.emarefa.net/detail/BIM-502593
American Medical Association (AMA)
Ho, Gilbert J.& Liang, Willie& Waragai, Masaaki& Sekiyama, Kazunari& Masliah, Eliezer& Hashimoto, Makoto. Bridging Molecular Genetics and Biomarkers in Lewy Body and Related Disorders. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-18.
https://search.emarefa.net/detail/BIM-502593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502593