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The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus
Joint Authors
Wang, Qingqing
Xu, Yulan
Zhang, Nan
Zhang, Beibei
Xu, Hongdi
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To study the correlations between serum osteocalcin and glucose metabolism in patients with type 2 diabetes, 66 cases were collected to determine total osteocalcin, undercarboxylated osteocalcin, fasting blood glucose, fasting insulin, and HbA1c.
Osteocalcin concentrations were compared between groups of different levels of HbA1c, and parameters of glucose metabolism were compared between groups of different levels of total osteocalcin and undercarboxylated osteocalcin.
The relationship between osteocalcin and parameters of glucose metabolism was also analyzed.
We found that the total osteocalcin concentration of high-HbA1c group was significantly lower than that of low-HbA1c group.
The fasting blood glucose of low-total-osteocalcin group was significantly higher than that of high-total-osteocalcin group in male participants, while the fasting blood glucose of low-undercarboxylated-osteocalcin group was significantly higher than that of high-undercarboxylated-osteocalcin group in all participants and in male participants.
Total osteocalcin was inversely correlated with HbA1c, and undercarboxylated osteocalcin was inversely correlated with fasting blood glucose.
However, no significant correlation was found between osteocalcin and HOMA-IR.
Total osteocalcin was an independent related factor of HbA1c level.
In summary, decreased serum total osteocalcin and undercarboxylated osteocalcin are closely related to the exacerbation of glucose metabolism disorder but have no relations with insulin resistance.
American Psychological Association (APA)
Wang, Qingqing& Zhang, Beibei& Xu, Yulan& Xu, Hongdi& Zhang, Nan. 2013. The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-502611
Modern Language Association (MLA)
Wang, Qingqing…[et al.]. The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-502611
American Medical Association (AMA)
Wang, Qingqing& Zhang, Beibei& Xu, Yulan& Xu, Hongdi& Zhang, Nan. The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-502611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502611