Structure of N-(3,4-Dimethoxyphenyl)pyrido[3′,2′ : 4,5]-thieno[3,2-d]pyrimidin-4-amine, a New Inhibitor of CLK1 and DYRK1A Kinases
Joint Authors
Besson, Thierry
Loidreau, Yvonnick
Marchivie, Mathieu
Pinaud, Noël
Guillon, Jean
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The complete crystal structure of N-(3,4-dimethoxyphenyl)pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amine, synthesized via a Dimroth rearrangement and designed as new inhibitor of CLK1 and DYRK1A kinases, was established by a single-crystal X-ray diffraction.
The crystal is orthorhombic, space group Pca21; a = 13.1593 (9), b = 13.9823 (10), c=8.5403 (7) Å, α=β=γ=90°, V = 1571.4 (2) Å3, and Z=4, C17H14N4O2S.
Solid-state data could be used to enlighten the biological mechanism of action.
American Psychological Association (APA)
Guillon, Jean& Marchivie, Mathieu& Loidreau, Yvonnick& Pinaud, Noël& Besson, Thierry. 2013. Structure of N-(3,4-Dimethoxyphenyl)pyrido[3′,2′ : 4,5]-thieno[3,2-d]pyrimidin-4-amine, a New Inhibitor of CLK1 and DYRK1A Kinases. Journal of Crystallography،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-502638
Modern Language Association (MLA)
Guillon, Jean…[et al.]. Structure of N-(3,4-Dimethoxyphenyl)pyrido[3′,2′ : 4,5]-thieno[3,2-d]pyrimidin-4-amine, a New Inhibitor of CLK1 and DYRK1A Kinases. Journal of Crystallography No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-502638
American Medical Association (AMA)
Guillon, Jean& Marchivie, Mathieu& Loidreau, Yvonnick& Pinaud, Noël& Besson, Thierry. Structure of N-(3,4-Dimethoxyphenyl)pyrido[3′,2′ : 4,5]-thieno[3,2-d]pyrimidin-4-amine, a New Inhibitor of CLK1 and DYRK1A Kinases. Journal of Crystallography. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-502638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502638
