Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice
Joint Authors
Jiang, Yi-Wen
Zhang, Yun-Yi
Li, Hong
Jiang, Yi-Fan
Chen, Dao-Feng
Ou, Ying-Ye
Li, Wen
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease leading to inflammatory tissue damage in multiple organs.
The crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var.
parvifolium have anticomplementary activity and immunomodulatory functions on macrophages.
To study its potential benefit on SLE, we examined effects of BPs on MRL-lpr mice, which have similar disease features to human SLE.
MRL-lpr mice were treated orally with BPs 15, 30, or 60 mg kg−1 day−1 for 12 weeks and their SLE characteristics were evaluated.
The results revealed that BPs elongated life span, improved kidney function, delayed lymphadenopathy, and reduced autoantibodies.
It seemed to be mediated by inhibition of complement and macrophages activation and suppression of interferon-γ (IFN-γ) and interleukin-6 (IL-6) gene expression in the kidney.
These results implicate that BPs may be an immunomodulator for the treatment of autoimmune diseases like SLE.
American Psychological Association (APA)
Jiang, Yi-Wen& Li, Hong& Zhang, Yun-Yi& Li, Wen& Jiang, Yi-Fan& Ou, Ying-Ye…[et al.]. 2012. Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-502664
Modern Language Association (MLA)
Jiang, Yi-Wen…[et al.]. Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice. Clinical and Developmental Immunology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-502664
American Medical Association (AMA)
Jiang, Yi-Wen& Li, Hong& Zhang, Yun-Yi& Li, Wen& Jiang, Yi-Fan& Ou, Ying-Ye…[et al.]. Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-502664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502664