Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma
Joint Authors
Martiniani, Roberta
Di Sano, Chiara
Liberati, Anna Marina
Lombardo, Alessandra
Di Loreto, Valentina
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lenalidomide is a synthetic compound derived by modifying the chemical structure of thalidomide.
It belongs to the second generation of immunomodulatory drugs (IMiDs) and possesses pleiotropic properties.
Even if lenalidomide has been shown to be active in the treatment of several hematologic malignancies, this review article is mostly focalized on its mode of action in multiple myeloma.
The present paper is about the direct and indirect antitumor effects of lenalidomide on malignant plasmacells, bone marrow microenvironment, bone resorption and host’s immune response.
The molecular mechanisms and targets of lenalidomide remain largely unknown, but recent evidence shows cereblon (CRBN) as a possible mediator of its therapeutical effects.
American Psychological Association (APA)
Martiniani, Roberta& Di Loreto, Valentina& Di Sano, Chiara& Lombardo, Alessandra& Liberati, Anna Marina. 2012. Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma. Advances in Hematology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-502666
Modern Language Association (MLA)
Martiniani, Roberta…[et al.]. Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma. Advances in Hematology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-502666
American Medical Association (AMA)
Martiniani, Roberta& Di Loreto, Valentina& Di Sano, Chiara& Lombardo, Alessandra& Liberati, Anna Marina. Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-502666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502666