Neurotoxicity Caused by the Treatment with Platinum Analogues
Joint Authors
Amptoulach, Sousana
Tsavaris, Nicolas
Source
Chemotherapy Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Platinum agents (cisplatin, carboplatin, and oxaliplatin) are a class of chemotherapy agents that have a broad spectrum of activity against several solid tumors.
Toxicity to the peripheral nervous system is the major dose-limiting toxicity of at least some of the platinum drugs of clinical interest.
Among the platinum compounds in clinical use, cisplatin is the most neurotoxic, inducing mainly sensory neuropathy of the upper and lower extremities.
Carboplatin is generally considered to be less neurotoxic than cisplatin, but it is associated with a higher risk of neurological dysfunction if administered at high dose or in combination with agents considered to be neurotoxic.
Oxaliplatin induces two types of peripheral neuropathy, acute and chronic.
The incidence of oxaliplatin-induced neuropathy is related to various risk factors such as treatment schedule, cumulative dose, and time of infusion.
To date, several neuroprotective agents including thiol compounds, vitamin E, various anticonvulsants, calcium-magnesium infusions, and other nonpharmacological strategies have been tested for their ability to prevent platinum-induced neurotoxicity with controversial results.
Further studies on the prevention and treatment of neurotoxicity of platinum analogues are warranted.
American Psychological Association (APA)
Amptoulach, Sousana& Tsavaris, Nicolas. 2011. Neurotoxicity Caused by the Treatment with Platinum Analogues. Chemotherapy Research and Practice،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-502672
Modern Language Association (MLA)
Amptoulach, Sousana& Tsavaris, Nicolas. Neurotoxicity Caused by the Treatment with Platinum Analogues. Chemotherapy Research and Practice No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-502672
American Medical Association (AMA)
Amptoulach, Sousana& Tsavaris, Nicolas. Neurotoxicity Caused by the Treatment with Platinum Analogues. Chemotherapy Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-502672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502672