PI3KAKTPTEN Signaling as a Molecular Target in Leukemia Angiogenesis
Joint Authors
Okumura, Naoko
Murakami, Mutsumi
Nishimura, Yuri
Kitagishi, Yasuko
Matsuda, Satoru
Yoshida, Hitomi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia.
The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene.
The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated.
However, it has become an attractive target for drug therapy against leukemia, because angiogenesis is a key process in malignant cell growth.
In this paper, we will focus on the roles and mechanisms of PI3K/AKT/PTEN pathway in regulating angiogenesis.
American Psychological Association (APA)
Okumura, Naoko& Yoshida, Hitomi& Kitagishi, Yasuko& Murakami, Mutsumi& Nishimura, Yuri& Matsuda, Satoru. 2012. PI3KAKTPTEN Signaling as a Molecular Target in Leukemia Angiogenesis. Advances in Hematology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-502675
Modern Language Association (MLA)
Okumura, Naoko…[et al.]. PI3KAKTPTEN Signaling as a Molecular Target in Leukemia Angiogenesis. Advances in Hematology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-502675
American Medical Association (AMA)
Okumura, Naoko& Yoshida, Hitomi& Kitagishi, Yasuko& Murakami, Mutsumi& Nishimura, Yuri& Matsuda, Satoru. PI3KAKTPTEN Signaling as a Molecular Target in Leukemia Angiogenesis. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-502675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502675
