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Tipping the Proteome with Gene-Based Vaccines : Weighing in on the Role of Nanomaterials
Joint Authors
Wanekaya, Adam
Ghosh, Kartik
Craig, Michael M.
DeLong, Robert K.
Smith, Joshua J.
Flores, Kristin J.
Dong, Lifeng
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Abstract EN
Since the first generation of DNA vaccines was introduced in 1988, remarkable improvements have been made to improve their efficacy and immunogenicity.
Although human clinical trials have shown that delivery of DNA vaccines is well tolerated and safe, the potency of these vaccines in humans is somewhat less than optimal.
The development of a gene-based vaccine that was effective enough to be approved for clinical use in humans would be one of, if not the most important, advance in vaccines to date.
This paper highlights the literature relating to gene-based vaccines, specifically DNA vaccines, and suggests possible approaches to boost their performance.
In addition, we explore the idea that combining RNA and nanomaterials may hold the key to successful gene-based vaccines for prevention and treatment of disease.
American Psychological Association (APA)
Flores, Kristin J.& Craig, Michael M.& Wanekaya, Adam& Dong, Lifeng& Ghosh, Kartik& Smith, Joshua J.…[et al.]. 2012. Tipping the Proteome with Gene-Based Vaccines : Weighing in on the Role of Nanomaterials. Journal of Nanotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-502684
Modern Language Association (MLA)
Flores, Kristin J.…[et al.]. Tipping the Proteome with Gene-Based Vaccines : Weighing in on the Role of Nanomaterials. Journal of Nanotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-502684
American Medical Association (AMA)
Flores, Kristin J.& Craig, Michael M.& Wanekaya, Adam& Dong, Lifeng& Ghosh, Kartik& Smith, Joshua J.…[et al.]. Tipping the Proteome with Gene-Based Vaccines : Weighing in on the Role of Nanomaterials. Journal of Nanotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-502684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502684