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Functional Subunits of Eukaryotic Chaperonin CCTTRiC in Protein Folding
Joint Authors
Jairajpuri, M. Aman
Kabir, Mohammad Anaul
Narayanan, Aswathy
Reddy, Praveen Kumar
Sherman, Fred
Uddin, Wasim
Ahmad, Zulfiqar
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-02
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Molecular chaperones are a class of proteins responsible for proper folding of a large number of polypeptides in both prokaryotic and eukaryotic cells.
Newly synthesized polypeptides are prone to nonspecific interactions, and many of them make toxic aggregates in absence of chaperones.
The eukaryotic chaperonin CCT is a large, multisubunit, cylindrical structure having two identical rings stacked back to back.
Each ring is composed of eight different but similar subunits and each subunit has three distinct domains.
CCT assists folding of actin, tubulin, and numerous other cellular proteins in an ATP-dependent manner.
The catalytic cooperativity of ATP binding/hydrolysis in CCT occurs in a sequential manner different from concerted cooperativity as shown for GroEL.
Unlike GroEL, CCT does not have GroES-like cofactor, rather it has a built-in lid structure responsible for closing the central cavity.
The CCT complex recognizes its substrates through diverse mechanisms involving hydrophobic or electrostatic interactions.
Upstream factors like Hsp70 and Hsp90 also work in a concerted manner to transfer the substrate to CCT.
Moreover, prefoldin, phosducin-like proteins, and Bag3 protein interact with CCT and modulate its function for the fine-tuning of protein folding process.
Any misregulation of protein folding process leads to the formation of misfolded proteins or toxic aggregates which are linked to multiple pathological disorders.
American Psychological Association (APA)
Kabir, Mohammad Anaul& Uddin, Wasim& Narayanan, Aswathy& Reddy, Praveen Kumar& Jairajpuri, M. Aman& Sherman, Fred…[et al.]. 2011. Functional Subunits of Eukaryotic Chaperonin CCTTRiC in Protein Folding. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-502691
Modern Language Association (MLA)
Kabir, Mohammad Anaul…[et al.]. Functional Subunits of Eukaryotic Chaperonin CCTTRiC in Protein Folding. Journal of Amino Acids No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-502691
American Medical Association (AMA)
Kabir, Mohammad Anaul& Uddin, Wasim& Narayanan, Aswathy& Reddy, Praveen Kumar& Jairajpuri, M. Aman& Sherman, Fred…[et al.]. Functional Subunits of Eukaryotic Chaperonin CCTTRiC in Protein Folding. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-502691
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502691