Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads
Joint Authors
Linscheid, Michael W.
Handoussa, Heba
Ayoub, Nahla
El-Khatib, Ahmed H.
El Sayed, Nesrine
Hassaan, Yara
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Epidemiological studies have proven an association between consumption of polyphenols and prevention of Alzheimer’s disease, the most common form of dementia characterized by extracellular deposition of amyloid beta plaques.
The aim of this study is pharmacological screening of the aqueous alcohol extract of Markhamia platycalyx leaves, Schotia brachypetala leaves and stalks, and piceatannol compared to aqueous alcohol extract of Camellia sinensis leaves as potential Alzheimer’s disease drugs.
LC-HRESI(-ve)-MSn was performed to identify phenolics’ profile of Schotia brachypetala stalks aqueous alcohol extract and revealed ten phenolic compounds as first report: daidzein, naringin, procyanidin isomers, procyanidin dimer gallate, quercetin 3-O-rhamnoside, quercetin 3-O-glucuronide, quercetin hexose gallic acid, quercetin hexose protocatechuic acid, and ellagic acid.
Alzheimer’s disease was induced by a single intraperitoneal injection of LPS.
Adult male Swiss albino mice were divided into groups of 8–10 mice each receiving treatment for six days.
In vivo behavioral tests (Y maze and object recognition) and in vitro estimation of amyloid beta 42 by ELISA showed significant differences between results of treated and nontreated animals.
American Psychological Association (APA)
Hassaan, Yara& Handoussa, Heba& El-Khatib, Ahmed H.& Linscheid, Michael W.& El Sayed, Nesrine& Ayoub, Nahla. 2014. Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-502699
Modern Language Association (MLA)
Hassaan, Yara…[et al.]. Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-502699
American Medical Association (AMA)
Hassaan, Yara& Handoussa, Heba& El-Khatib, Ahmed H.& Linscheid, Michael W.& El Sayed, Nesrine& Ayoub, Nahla. Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-502699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502699