Pathological Significance of Mitochondrial Glycation
Joint Authors
Murphy, Michael P.
Pun, Pamela Boon Li
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Glycation, the nonenzymatic glycosylation of biomolecules, is commonly observed in diabetes and ageing.
Reactive dicarbonyl species such as methylglyoxal and glyoxal are thought to be major physiological precursors of glycation.
Because these dicarbonyls tend to be formed intracellularly, the levels of advanced glycation end products on cellular proteins are higher than on extracellular ones.
The formation of glycation adducts within cells can have severe functional consequences such as inhibition of protein activity and promotion of DNA mutations.
Although several lines of evidence suggest that there are specific mitochondrial targets of glycation, and mitochondrial dysfunction itself has been implicated in disease and ageing, it is unclear if glycation of biomolecules specifically within mitochondria induces dysfunction and contributes to disease pathology.
We discuss here the possibility that mitochondrial glycation contributes to disease, focussing on diabetes, ageing, cancer, and neurodegeneration, and highlight the current limitations in our understanding of the pathological significance of mitochondrial glycation.
American Psychological Association (APA)
Pun, Pamela Boon Li& Murphy, Michael P.. 2012. Pathological Significance of Mitochondrial Glycation. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502717
Modern Language Association (MLA)
Pun, Pamela Boon Li& Murphy, Michael P.. Pathological Significance of Mitochondrial Glycation. International Journal of Cell Biology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-502717
American Medical Association (AMA)
Pun, Pamela Boon Li& Murphy, Michael P.. Pathological Significance of Mitochondrial Glycation. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-502717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502717