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Robust Joint Analysis with Data Fusion in Two-Stage Quantitative Trait Genome-Wide Association Studies
Joint Authors
Pan, Dong-Dong
Fung, Wing-Kam
Pan, Ying
Xiong, Wen-Jun
Zhou, Guo-Li
Zhou, Ji-Yuan
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Genome-wide association studies (GWASs) in identifying the disease-associated genetic variants have been proved to be a great pioneering work.
Two-stage design and analysis are often adopted in GWASs.
Considering the genetic model uncertainty, many robust procedures have been proposed and applied in GWASs.
However, the existing approaches mostly focused on binary traits, and few work has been done on continuous (quantitative) traits, since the statistical significance of these robust tests is difficult to calculate.
In this paper, we develop a powerful F-statistic-based robust joint analysis method for quantitative traits using the combined raw data from both stages in the framework of two-staged GWASs.
Explicit expressions are obtained to calculate the statistical significance and power.
We show using simulations that the proposed method is substantially more robust than the F-test based on the additive model when the underlying genetic model is unknown.
An example for rheumatic arthritis (RA) is used for illustration.
American Psychological Association (APA)
Pan, Dong-Dong& Xiong, Wen-Jun& Zhou, Ji-Yuan& Pan, Ying& Zhou, Guo-Li& Fung, Wing-Kam. 2013. Robust Joint Analysis with Data Fusion in Two-Stage Quantitative Trait Genome-Wide Association Studies. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-502723
Modern Language Association (MLA)
Pan, Dong-Dong…[et al.]. Robust Joint Analysis with Data Fusion in Two-Stage Quantitative Trait Genome-Wide Association Studies. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-502723
American Medical Association (AMA)
Pan, Dong-Dong& Xiong, Wen-Jun& Zhou, Ji-Yuan& Pan, Ying& Zhou, Guo-Li& Fung, Wing-Kam. Robust Joint Analysis with Data Fusion in Two-Stage Quantitative Trait Genome-Wide Association Studies. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-502723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502723