![](/images/graphics-bg.png)
Mathematical Model of the Effect of Interstitial Fluid Pressure on Angiogenic Behavior in Solid Tumors
Joint Authors
Phipps, Colin
Kohandel, Mohammad
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We present a mathematical model for the concentrations of proangiogenic and antiangiogenic growth factors, and their resulting balance/imbalance, in host and tumor tissue.
In addition to production, diffusion, and degradation of these angiogenic growth factors (AGFs), we include interstitial convection to study the locally destabilizing effects of interstitial fluid pressure (IFP) on the activity of these factors.
The molecular sizes of representative AGFs and the outward flow of interstitial fluid in tumors suggest that convection is a significant mode of transport for these molecules.
The results of our modeling approach suggest that changes in the physiological parameters that determine interstitial fluid pressure have as profound an impact on tumor angiogenesis as those parameters controlling production, diffusion, and degradation of AGFs.
This model has predictive potential for determining the angiogenic behavior of solid tumors and the effects of cytotoxic and antiangiogenic therapies on tumor angiogenesis.
American Psychological Association (APA)
Phipps, Colin& Kohandel, Mohammad. 2011. Mathematical Model of the Effect of Interstitial Fluid Pressure on Angiogenic Behavior in Solid Tumors. Computational and Mathematical Methods in Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-502743
Modern Language Association (MLA)
Phipps, Colin& Kohandel, Mohammad. Mathematical Model of the Effect of Interstitial Fluid Pressure on Angiogenic Behavior in Solid Tumors. Computational and Mathematical Methods in Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-502743
American Medical Association (AMA)
Phipps, Colin& Kohandel, Mohammad. Mathematical Model of the Effect of Interstitial Fluid Pressure on Angiogenic Behavior in Solid Tumors. Computational and Mathematical Methods in Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-502743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502743