Mining the Virgin Land of Neurotoxicology : A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels
Joint Authors
Liu, Zhirui
Ji, Yonghua
Ye, Pin
Tao, Jie
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Voltage-gated sodium channels (VGSCs) are important membrane protein carrying on the molecular basis for action potentials (AP) in neuronal firings.
Even though the structure-function studies were the most pursued spots, the posttranslation modification processes, such as glycosylation, phosphorylation, and alternative splicing associating with channel functions captured less eyesights.
The accumulative research suggested an interaction between the sialic acids chains and ion-permeable pores, giving rise to subtle but significant impacts on channel gating.
Sodium channel-specific neurotoxic toxins, a family of long-chain polypeptides originated from venomous animals, are found to potentially share the binding sites adjacent to glycosylated region on VGSCs.
Thus, an interaction between toxin and glycosylated VGSC might hopefully join the campaign to approach the role of glycosylation in modulating VGSCs-involved neuronal network activity.
This paper will cover the state-of-the-art advances of researches on glycosylation-mediated VGSCs function and the possible underlying mechanisms of interactions between toxin and glycosylated VGSCs, which may therefore, fulfill the knowledge in identifying the pharmacological targets and therapeutic values of VGSCs.
American Psychological Association (APA)
Liu, Zhirui& Tao, Jie& Ye, Pin& Ji, Yonghua. 2012. Mining the Virgin Land of Neurotoxicology : A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-502747
Modern Language Association (MLA)
Liu, Zhirui…[et al.]. Mining the Virgin Land of Neurotoxicology : A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels. Journal of Toxicology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-502747
American Medical Association (AMA)
Liu, Zhirui& Tao, Jie& Ye, Pin& Ji, Yonghua. Mining the Virgin Land of Neurotoxicology : A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-502747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502747