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Morphometric Analysis of Nonsclerosed Glomeruli Size and Connective Tissue Content during the Aging Process
Joint Authors
Jocić, Miodrag V.
Ugrenović, Sladjana Z.
Jovanović, Ivan D.
Živković, Vladimir S.
Kundalić, Braca K.
Stojanović, Vesna R.
Vasović, Ljiljana P.
Pavlović, Miljana N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Number of sclerotic glomeruli increases during the aging process.
Consequently, majority of remained nonsclerosed glomeruli become hypertrophic and some of them sclerotic, too.
The aim of this study was to quantify the size and connective tissue content of nonsclerosed glomeruli and to evaluate the percentage of hypertrophic ones in examined human cases during the aging.
Material was right kidney's tissue of 30 cadavers obtained during routine autopsies.
Cadavers were without previously diagnosed kidney disease, diabetes, hypertension, or any other systemic disease.
Tissue specimens were routinely prepared for histological and morphometric analysis.
Images of the histological slices were analyzed and captured under 400x magnification with digital camera.
Further they were morphometrically and statistically analyzed with ImageJ and NCSS-PASS software.
Multiple and linear regression of obtained morphometric parameters showed significant increase of glomerular connective tissue area and percentage.
Cluster analysis showed the presence of two types of glomeruli.
Second type was characterized with significantly larger size, connective tissue content, and significantly lower cellularity, in relation to the first type.
Such glomeruli might be considered as hypertrophic.
First type of glomeruli was predominant in younger cases, while second type of glomeruli was predominant in cases older than 55 years.
American Psychological Association (APA)
Stojanović, Vesna R.& Jovanović, Ivan D.& Ugrenović, Sladjana Z.& Vasović, Ljiljana P.& Živković, Vladimir S.& Jocić, Miodrag V.…[et al.]. 2012. Morphometric Analysis of Nonsclerosed Glomeruli Size and Connective Tissue Content during the Aging Process. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502761
Modern Language Association (MLA)
Stojanović, Vesna R.…[et al.]. Morphometric Analysis of Nonsclerosed Glomeruli Size and Connective Tissue Content during the Aging Process. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-502761
American Medical Association (AMA)
Stojanović, Vesna R.& Jovanović, Ivan D.& Ugrenović, Sladjana Z.& Vasović, Ljiljana P.& Živković, Vladimir S.& Jocić, Miodrag V.…[et al.]. Morphometric Analysis of Nonsclerosed Glomeruli Size and Connective Tissue Content during the Aging Process. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502761