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Genotype by Energy Expenditure Interaction and Body Composition Traits : The Portuguese Healthy Family Study
Joint Authors
Gomes, T. N.
Maia, J. A.
Katzmarzyk, P. T.
Santos, F. K.
Santos, D. M.
Blangero, John
Diego, V. P.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background and Aims.
Energy expenditure has been negatively correlated with fat accumulation.
However, this association is highly variable.
In the present study we applied a genotype by environment interaction method to examine the presence of Genotype x by Total Daily Energy Expenditure and Genotype x by Daily Energy Expenditure interactions in the expression of different body composition traits.
Methods and Results.
A total of 958 subjects from 294 families of The Portuguese Healthy Family Study were included in the analysis.
TDEE and DEE were assessed using a physical activity recall.
Body fat percentages were measured with a bioelectrical impedance scale.
GxTDEE and GxDEE examinations were performed using SOLAR 4.0 software.
All BC traits were significantly heritable, with heritabilities ranging from 21% to 34%.
The GxTDEE and GxDEE interaction models fitted the data better than the polygenic model for all traits.
For all traits, a significant GxTDEE and GxDEE interaction was due to variance heterogeneity among distinct levels of TDEE and DEE.
For WC, GxTDEE was also significant due to the genetic correlation function.
Conclusions.
TDEE and DEE are environmental constraints associated with the expression of individuals’ BC genotypes, leading to variability in the phenotypic expression of BC traits.
American Psychological Association (APA)
Santos, D. M.& Katzmarzyk, P. T.& Diego, V. P.& Gomes, T. N.& Santos, F. K.& Blangero, John…[et al.]. 2014. Genotype by Energy Expenditure Interaction and Body Composition Traits : The Portuguese Healthy Family Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-502781
Modern Language Association (MLA)
Santos, D. M.…[et al.]. Genotype by Energy Expenditure Interaction and Body Composition Traits : The Portuguese Healthy Family Study. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-502781
American Medical Association (AMA)
Santos, D. M.& Katzmarzyk, P. T.& Diego, V. P.& Gomes, T. N.& Santos, F. K.& Blangero, John…[et al.]. Genotype by Energy Expenditure Interaction and Body Composition Traits : The Portuguese Healthy Family Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-502781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502781