Modulation of Human Colostrum Phagocyte Activity by the Glycine-Adsorbed Polyethylene Glycol Microspheres
Joint Authors
Fagundes, Danny Laura Gomes
França, Eduardo Luzía
Ratto, Silvia Hanna Bilotti
Guimarães, Paulo Celso Leventi
Honorio-França, Adenilda Cristina
Hara, Cristiane de Castro Pernet
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Colostrum is a secretion that contains immunologically active components, including immunocompetent cells and glycine, which has anti-inflammatory, immunomodulatory, and cytoprotective effects.
The aim of this study was to evaluate the adsorption of glycine onto polyethylene glycol (PEG) microspheres and to verify the immunomodulatory effect of this nanomaterial on human colostrum phagocytes.
The PEG microspheres were evaluated by fluorescence microscopy.
The effects of PEG microspheres with adsorbed glycine on viability, superoxide release, phagocytosis, microbicidal activity, and intracellular calcium release of mononuclear (MN) and polymorphonuclear (PMN) colostrum phagocytes were determined.
Fluorescence microscopy analyses revealed that glycine was able to be adsorbed to the PEG microspheres.
The PMN phagocytes exposed to glycine-PEG microspheres showed the highest superoxide levels.
The phagocytes (both MN and PMN) displayed increased microbicidal activity and intracellular calcium release in the presence of PEG microspheres with adsorbed glycine.
These data suggest that the adsorption of PEG microspheres with adsorbed glycine was able to stimulate the colostrum phagocytes.
This material may represent a possible alternative therapy for future clinical applications on patients with gastrointestinal infections.
American Psychological Association (APA)
Guimarães, Paulo Celso Leventi& Honorio-França, Adenilda Cristina& Hara, Cristiane de Castro Pernet& Fagundes, Danny Laura Gomes& Ratto, Silvia Hanna Bilotti& França, Eduardo Luzía. 2013. Modulation of Human Colostrum Phagocyte Activity by the Glycine-Adsorbed Polyethylene Glycol Microspheres. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502785
Modern Language Association (MLA)
Guimarães, Paulo Celso Leventi…[et al.]. Modulation of Human Colostrum Phagocyte Activity by the Glycine-Adsorbed Polyethylene Glycol Microspheres. Journal of Chemistry No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-502785
American Medical Association (AMA)
Guimarães, Paulo Celso Leventi& Honorio-França, Adenilda Cristina& Hara, Cristiane de Castro Pernet& Fagundes, Danny Laura Gomes& Ratto, Silvia Hanna Bilotti& França, Eduardo Luzía. Modulation of Human Colostrum Phagocyte Activity by the Glycine-Adsorbed Polyethylene Glycol Microspheres. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502785