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The Bright and the Dark Sides of DNA Repair in Stem Cells
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-08
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
DNA repair is a double-edged sword in stem cells.
It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues.
Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells.
Upon differentiation, a certain degree of somatic mutations becomes more acceptable and, consequently, DNA repair dims.
DNA repair turns into a problem when stem cells transform and become cancerous.
Transformed stem cells drive growth of a number of tumours (e.g., high grade gliomas) and being particularly resistant to chemo- and radiotherapeutic agents often cause relapses.
The contribution of DNA repair to resistance of these tumour-driving cells is the subject of intense research, in order to find novel agents that may sensitize them to chemotherapy and radiotherapy.
American Psychological Association (APA)
Frosina, Guido. 2010. The Bright and the Dark Sides of DNA Repair in Stem Cells. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-502796
Modern Language Association (MLA)
Frosina, Guido. The Bright and the Dark Sides of DNA Repair in Stem Cells. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-502796
American Medical Association (AMA)
Frosina, Guido. The Bright and the Dark Sides of DNA Repair in Stem Cells. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-502796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502796