Epigenetic Control of Circadian Clock Operation during Development
Joint Authors
Wu, Jianguo
Li, Chengwei
Li, Xiaodong
Yu, Shuang
Gong, Changxia
Source
Genetics Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The molecular players of circadian clock oscillation have been identified and extensively characterized.
The epigenetic mechanisms behind the circadian gene expression control has also been recently studied, although there are still details to be illucidated.
In this review, we briefly summarize the current understanding of the mammalian clock.
We also provide evidence for the lack of circadian oscillation in particular cell types.
As the circadian clock has intimate interaction with the various cellular functions in different type of cells, it must have plasticity and specicity in its operation within different epigenetic environments.
The lack of circadian oscillation in certain cells provide an unique opportunity to study the required epigenetic environment in the cell that permit circadian oscillation and to idenfify key influencing factors for proper clock function.
How epigenetic mechansims, including DNA methylaiton and chromatin modifications, participate in control of clock oscillation still awaits future studies at the genomic scale.
American Psychological Association (APA)
Li, Chengwei& Gong, Changxia& Yu, Shuang& Wu, Jianguo& Li, Xiaodong. 2012. Epigenetic Control of Circadian Clock Operation during Development. Genetics Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502803
Modern Language Association (MLA)
Li, Chengwei…[et al.]. Epigenetic Control of Circadian Clock Operation during Development. Genetics Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-502803
American Medical Association (AMA)
Li, Chengwei& Gong, Changxia& Yu, Shuang& Wu, Jianguo& Li, Xiaodong. Epigenetic Control of Circadian Clock Operation during Development. Genetics Research International. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-502803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502803