Classic and New Animal Models of Parkinson's Disease
Joint Authors
Jackson-Lewis, Vernice
Phani, Sudarshan
Blesa, Javier
Przedborski, Serge
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neurological disorders can be modeled in animals so as to recreate specific pathogenic events and behavioral outcomes.
Parkinson’s Disease (PD) is the second most common neurodegenerative disease of an aging population, and although there have been several significant findings about the PD disease process, much of this process still remains a mystery.
Breakthroughs in the last two decades using animal models have offered insights into the understanding of the PD disease process, its etiology, pathology, and molecular mechanisms.
Furthermore, while cellular models have helped to identify specific events, animal models, both toxic and genetic, have replicated almost all of the hallmarks of PD and are useful for testing new neuroprotective or neurorestorative strategies.
Moreover, significant advances in the modeling of additional PD features have come to light in both classic and newer models.
In this review, we try to provide an updated summary of the main characteristics of these models as well as the strengths and weaknesses of what we believe to be the most popular PD animal models.
These models include those produced by 6-hydroxydopamine (6-OHDA), 1-methyl-1,2,3,6-tetrahydropiridine (MPTP), rotenone, and paraquat, as well as several genetic models like those related to alpha-synuclein, PINK1, Parkin and LRRK2 alterations.
American Psychological Association (APA)
Blesa, Javier& Phani, Sudarshan& Jackson-Lewis, Vernice& Przedborski, Serge. 2012. Classic and New Animal Models of Parkinson's Disease. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-502811
Modern Language Association (MLA)
Blesa, Javier…[et al.]. Classic and New Animal Models of Parkinson's Disease. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-502811
American Medical Association (AMA)
Blesa, Javier& Phani, Sudarshan& Jackson-Lewis, Vernice& Przedborski, Serge. Classic and New Animal Models of Parkinson's Disease. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-502811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502811