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Do Not Be Fooled by Fancy Mutations : Inflammatory Fibroid Polyps Can Harbor Mutations Similar to Those Found in GIST
Joint Authors
Steigen, Sonja E.
Aaberg, Kristin
Bjerkehagen, Bodil
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Goal.
Surgeons that remove a typical polyp from the stomach or small intestine should be reluctant to accept a diagnosis of GIST just because there is a mutation in platelet-derived growth factor receptor alfa (PDGFRA).
Background.
A subtype of gastric and intestinal polyps is denoted as inflammatory fibroid polyp (IFP).
In some of these cases a mutation in PDGFRA is found, leading to the diagnosis of gastrointestinal stromal tumor (GIST).
Study.
This study includes two patients that had polyps removed from the ileum, and an extended investigation was performed with immunohistochemical staining and mutation analyses.
Results.
The tumors did not show typical immunohistochemical staining for markers used to diagnose GIST, but the mutation analysis revealed a mutation in PDGFRA exon 12.
On the basis of the mutation analysis, both polyps were primarily diagnosed as GISTs, but the diagnosis was later changed to inflammatory fibroid polyp.
Conclusion.
It is important that both surgeons and pathologists be aware that IFP can harbor a mutation in PDGFRA where further treatment and follow-up is different with the two different diagnoses.
A mutation analysis can be misleading when taken out of the context of clinical observations, histological characteristics and immunohistochemical staining.
American Psychological Association (APA)
Bjerkehagen, Bodil& Aaberg, Kristin& Steigen, Sonja E.. 2013. Do Not Be Fooled by Fancy Mutations : Inflammatory Fibroid Polyps Can Harbor Mutations Similar to Those Found in GIST. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-502828
Modern Language Association (MLA)
Bjerkehagen, Bodil…[et al.]. Do Not Be Fooled by Fancy Mutations : Inflammatory Fibroid Polyps Can Harbor Mutations Similar to Those Found in GIST. Case Reports in Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-502828
American Medical Association (AMA)
Bjerkehagen, Bodil& Aaberg, Kristin& Steigen, Sonja E.. Do Not Be Fooled by Fancy Mutations : Inflammatory Fibroid Polyps Can Harbor Mutations Similar to Those Found in GIST. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-502828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502828