Hereditary Diffuse Gastric Cancer : Multidisciplinary Case Report with Review of the Literature
Joint Authors
Wilcox, Rebecca
Perpich, Melody
Cooper, Kumarasen
Posner, Mitchell C.
Noffsinger, Amy
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Hereditary diffuse gastric cancer (HDGC) is a rare, inherited cancer syndrome with at least one fourth of HDGC patients having an autosomal dominantly inherited mutation of CDH1 (E-Cadherin).
Penetrance is relatively high (70–80% lifetime risk for gastric cancer).
It is important for pathologists to recognize the syndrome's phenotype in early gastric lesions: patchy intramucosal signet ring cells often associated with pagetoid spread.
Due to the insidious nature of this lesion, surveillance is limited and currently prophylactic gastrectomy is an option chosen by many HDGC patients.
We present a case report from a multidisciplinary team of authors with a review of the literature that includes the updated guidelines for CDH1 genetic testing.
American Psychological Association (APA)
Wilcox, Rebecca& Perpich, Melody& Noffsinger, Amy& Posner, Mitchell C.& Cooper, Kumarasen. 2011. Hereditary Diffuse Gastric Cancer : Multidisciplinary Case Report with Review of the Literature. Pathology Research International،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-502833
Modern Language Association (MLA)
Wilcox, Rebecca…[et al.]. Hereditary Diffuse Gastric Cancer : Multidisciplinary Case Report with Review of the Literature. Pathology Research International No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-502833
American Medical Association (AMA)
Wilcox, Rebecca& Perpich, Melody& Noffsinger, Amy& Posner, Mitchell C.& Cooper, Kumarasen. Hereditary Diffuse Gastric Cancer : Multidisciplinary Case Report with Review of the Literature. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-502833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502833