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Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children
Joint Authors
Kheirandish-Gozal, Leila
Sans Capdevila, Oscar
Bhattacharjee, Rakesh
Gozal, David
Tauman, Riva
Khalyfa, Abdelnaby
Kim, Jinkwan
Source
International Journal of Pediatrics
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The impact of obesity as a systemic low-grade inflammatory process has only partially been explored.
To this effect, 704 community-based school-aged children (354 obese children and 350 age-, gender-, and ethnicity-matched controls) were recruited and underwent assessment of plasma levels of fasting insulin and glucose, lipids, and a variety of proinflammatory mediators that are associated with cardiometabolic dysfunction.
Obese children were at higher risk for abnormal HOMA and cholesterol levels.
Furthermore, BMI z score, HOMA, and LDL/HDL ratio strongly correlated with levels of certain inflammatory mediators.
Taken together, obesity in children is not only associated with insulin resistance and hyperlipidemia, but is accompanied by increased, yet variable, expression of markers of systemic inflammation.
Future community-based intervention and phenotype correlational studies on childhood obesity will require inclusion of expanded panels of inflammatory biomarkers to provide a comprehensive assessment of risk on specific obesity-related morbidities.
American Psychological Association (APA)
Kim, Jinkwan& Bhattacharjee, Rakesh& Kheirandish-Gozal, Leila& Khalyfa, Abdelnaby& Sans Capdevila, Oscar& Tauman, Riva…[et al.]. 2011. Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children. International Journal of Pediatrics،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-502859
Modern Language Association (MLA)
Kim, Jinkwan…[et al.]. Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children. International Journal of Pediatrics No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-502859
American Medical Association (AMA)
Kim, Jinkwan& Bhattacharjee, Rakesh& Kheirandish-Gozal, Leila& Khalyfa, Abdelnaby& Sans Capdevila, Oscar& Tauman, Riva…[et al.]. Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children. International Journal of Pediatrics. 2011. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-502859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502859