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Protective Effect of Standardized Extract of Ginkgo biloba against Cisplatin-Induced Nephrotoxicity
Joint Authors
Liu, Dan
Song, Jie
Feng, Liang
Xiao, Wei
Jia, Xiaobin
Zhang, Zhenhai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cisplatin (CDDP) is a potent antitumor compound widely used with a notably side effect of nephrotoxicity inducing oxidative stress and apoptosis in kidneys.
Standardized extract from the leaves of the Ginkgo biloba trees, labeled EGb761 (EGb), has been available on the market for its beneficial effects.
The purpose of this study was to investigate the ability of EGb to prevent the nephrotoxic effect of CDDP and the mechanisms involved.
Our results showed that EGb treatment restored the levels of creatinine, BUN, MDA, NO, SOD, CAT, GPx, and GSSG/GSH ratio in kidneys after CDDP injection.
EGb also exhibited a tendency to decrease the elevated NF-κB translocation and caspase-3 protein levels in CDDP-treated kidneys.
We further used a porcine kidney proximal tubular epithelial (LLC-PK1) cell line, finding that EGb accordingly inhibited ROS accumulation and iNOS increase induced by CDDP in vitro.
EGb also attenuated IκB degradation and p65 NF-κB phosphorylation triggered by CDDP in LLC-PK1 cells.
But EGb failed to influence CDDP-stimulated caspase cascade.
These findings suggested that EGb’s renoprotective effect might be mediated by not only its well-known antioxidant activity but also the anti-inflammatory activity.
American Psychological Association (APA)
Song, Jie& Liu, Dan& Feng, Liang& Zhang, Zhenhai& Jia, Xiaobin& Xiao, Wei. 2013. Protective Effect of Standardized Extract of Ginkgo biloba against Cisplatin-Induced Nephrotoxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-502862
Modern Language Association (MLA)
Song, Jie…[et al.]. Protective Effect of Standardized Extract of Ginkgo biloba against Cisplatin-Induced Nephrotoxicity. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-502862
American Medical Association (AMA)
Song, Jie& Liu, Dan& Feng, Liang& Zhang, Zhenhai& Jia, Xiaobin& Xiao, Wei. Protective Effect of Standardized Extract of Ginkgo biloba against Cisplatin-Induced Nephrotoxicity. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-502862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502862