U1 snRNP-Dependent Suppression of Polyadenylation : Physiological Role and Therapeutic Opportunities in Cancer
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pre-mRNA splicing and polyadenylation are critical steps in the maturation of eukaryotic mRNA.
U1 snRNP is an essential component of the splicing machinery and participates in splice-site selection and spliceosome assembly by base-pairing to the 5′ splice site.
U1 snRNP also plays an additional, nonsplicing global function in 3′ end mRNA processing; it actively suppresses the polyadenylation machinery from using early, mostly intronic polyadenylation signals which would lead to aberrant, truncated mRNAs.
Thus, U1 snRNP safeguards pre-mRNA transcripts against premature polyadenylation and contributes to the regulation of alternative polyadenylation.
Here, we review the role of U1 snRNP in 3′ end mRNA processing, outline the evidence that led to the recognition of its physiological, general role in inhibiting polyadenylation, and finally highlight the possibility of manipulating this U1 snRNP function for therapeutic purposes in cancer.
American Psychological Association (APA)
Spraggon, Lee& Cartegni, Luca. 2013. U1 snRNP-Dependent Suppression of Polyadenylation : Physiological Role and Therapeutic Opportunities in Cancer. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-502900
Modern Language Association (MLA)
Spraggon, Lee& Cartegni, Luca. U1 snRNP-Dependent Suppression of Polyadenylation : Physiological Role and Therapeutic Opportunities in Cancer. International Journal of Cell Biology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-502900
American Medical Association (AMA)
Spraggon, Lee& Cartegni, Luca. U1 snRNP-Dependent Suppression of Polyadenylation : Physiological Role and Therapeutic Opportunities in Cancer. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-502900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502900