Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells : Antiradiation Potential of Onions and Garlic
Joint Authors
Takahashi, Hiroyuki
Ishida, Yushi
Ozawa, Shuji
Endoh, Daiji
Chang, Hye-Sook
Hayashi, Masanobu
Yamato, Osamu
Yabuki, Akira
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
To evaluate a radioprotective effect of sodium n-propyl thiosulfate (NPTS) and sodium 2-propenyl thiosulfate (2PTS) derived from onions and garlic, respectively, rat hepatoma H4IIE cells and mouse lymphoma L5178Y cells were preincubated with each of these compounds for 48 hours at 37°C before receiving 10 Gy of X-ray irradiation.
Cell damage caused by the irradiation was quantified as comet tail moment, which represents the degree of DNA damage.
X-ray-induced DNA damage was significantly decreased in both H4IIE and L5178Y cells by micromolar concentrations of NPTS and 2PTS compared with the control without the compounds.
The protective effect was more potent with 2PTS than NPTS.
Onions and garlic have antiradiation potential.
American Psychological Association (APA)
Chang, Hye-Sook& Endoh, Daiji& Ishida, Yushi& Takahashi, Hiroyuki& Ozawa, Shuji& Hayashi, Masanobu…[et al.]. 2012. Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells : Antiradiation Potential of Onions and Garlic. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-502921
Modern Language Association (MLA)
Chang, Hye-Sook…[et al.]. Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells : Antiradiation Potential of Onions and Garlic. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-502921
American Medical Association (AMA)
Chang, Hye-Sook& Endoh, Daiji& Ishida, Yushi& Takahashi, Hiroyuki& Ozawa, Shuji& Hayashi, Masanobu…[et al.]. Radioprotective Effect of Alk(en)yl Thiosulfates Derived from Allium Vegetables against DNA Damage Caused by X-Ray Irradiation in Cultured Cells : Antiradiation Potential of Onions and Garlic. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-502921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502921
