Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure
Joint Authors
Hirooka, Yoshitaka
Kishi, Takuya
Source
Cardiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
It has been recognized that the sympathetic nervous system is abnormally activated in chronic heart failure, and leads to further worsening chronic heart failure.
In the treatment of chronic heart failure many clinical studies have already suggested that the inhibition of the abnormal sympathetic hyperactivity by beta blockers is beneficial.
It has been classically considered that abnormal sympathetic hyperactivity in chronic heart failure is caused by the enhancement of excitatory inputs including changes in peripheral baroreceptor and chemoreceptor reflexes and chemical mediators that control sympathetic outflow.
Recently, the abnormalities in the central regulation of sympathetic nerve activity mediated by brain renin angiotensin system-oxidative stress axis and/or proinflammatory cytokines have been focused.
Central renin angiotensin system, proinflammatory cytokines, and the interaction between them have been determined as the target of the sympathoinhibitory treatment in experimental animal models with chronic heart failure.
In conclusion, we must recognize that chronic heart failure is a syndrome with an abnormal sympathoexcitation, which is caused by the abnormalities in the central regulation of sympathetic nerve activity.
American Psychological Association (APA)
Kishi, Takuya& Hirooka, Yoshitaka. 2012. Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-502944
Modern Language Association (MLA)
Kishi, Takuya& Hirooka, Yoshitaka. Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure. Cardiology Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-502944
American Medical Association (AMA)
Kishi, Takuya& Hirooka, Yoshitaka. Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-502944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502944